Abstract
Enterotoxaemia (ET) is a fatal enteric disease of small ruminants attributable to a toxigenic type of Clostridium perfringens. The key strategy for prevention of ET is the management and vaccination. Present study aimed at identifying the sources of variation for ET vaccine response especially against epsilon toxin in 173 sheep that included 83 Avikalin and 90 Malpura lambs raised at the institute flock in the semi-arid region of India. The mean age at vaccination was 90 days. Sera were tested by blocking ELISA. Study showed significant variability for response to ET vaccine. 5.2% animals had + positivity, 20.8% animals had ++ positivity, 51.4% animals had +++ positivity and 22.5% animals had ++++ positivity. Amongst environmental determinants, breed, season, sex and age at vaccination proved to be non-significant sources of variation (P > 0.05). MHC genotypes with DRB1 gene and DQA2 genes also revealed non-significant association with ET vaccine response; however, a trend of decreasing PI values with increasing ranks was observed. Study revealed strong response of epsilon toxin along with complexity of the ET vaccine response as phenotype to be explained by genetic and non-genetic factors. The importance of better management practices and vaccination is suggested for preventive measures.
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Acknowledgements
Authors duly acknowledge the Department of Biotechnology (GOI) for project grant to carry out the desired work. Authors are thankful to the Director ICAR-CSWRI Avikanagar for providing facilities for carrying out the work. The authors are also thankful to the PC ICAR-MSSP for funding the nucleus breeding flock of Malpura sheep at the Institute. Similarly all the project team of Malpura sheep and Avikalin sheep are deeply acknowledged.
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Gowane, G.R., Akram, N., Prince, L.L.L. et al. Genetic appraisal of serological response post vaccination against enterotoxaemia (ET) in Malpura and Avikalin sheep. Trop Anim Health Prod 49, 867–873 (2017). https://doi.org/10.1007/s11250-017-1277-9
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DOI: https://doi.org/10.1007/s11250-017-1277-9